Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromomethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.45 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LAP3 | P28838 | 2/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4220437 | 0.95 | OPRM1 (0.55) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| SCHEMBL14722141 | 0.95 | OPRM1 (0.55) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| SCHEMBL28208768 | 0.95 | OPRM1 (0.55) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| SCHEMBL4373469 | 0.95 | OPRM1 (0.55) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| SCHEMBL5536187 | 0.95 | OPRM1 (0.55) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| SCHEMBL23093680 | 0.95 | OPRM1 (0.55) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| Iodide SCHEMBL28289281 | 0.92 | OPRM1 (0.52) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| SCHEMBL28260426 | 0.92 | OPRM1 (0.52) | OPRM1SPHK1LCKPPARDZDHHC20 | |
| SCHEMBL901170 | 0.92 | — | — | |
| Bromide SCHEMBL31416096 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481365-B1 | SOLUBILIZING AGENTS FOR UV FILTERS IN COSMETIC FORMULATIONS | BASF SE (DE) | 2021-09-08 | — | — | EP | disclosed |
| EP-1482904-B1 | UV ABSORBER COMPOSITIONS COMPRISING A HYDROXYPHENYLTRIAZINE COMPOUND | CIBA SC HOLDING AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| US-7344706-B2 | Benzotriazoles, dibenzoylmethane derivatives and camphor derivatives: Ultraviolet filters in cosmetic compositions | CIBA SPECIALTY CHEMICALS CORP. (US) | 2008-03-18 | — | — | US | disclosed |
| US-20050129632-A1 | Uv absorber compositions comprising a hydroxyphenyltriazine compound | CIBA SPECIALTY CHEMICALS CORP. | 2005-06-16 | — | — | US | disclosed |
| EP-1482904-A1 | UV ABSORBER COMPOSITIONS COMPRISING A HYDROXYPHENYLTRIAZINE COMPOUND | Ciba SC Holding AG (CH) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075875-A1 | UV ABSORBER COMPOSITIONS COMPRISING A HYDROXYPHENYLTRIAZINE COMPOUND | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050129632-A1 | Uv absorber compositions comprising a hydroxyphenyltriazine compound | C1R, C5, C3AR1 | OPRM1 3581/4885SPHK1 1303/4885LCK 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.