Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607498 | 0.75 | USP2 (0.58) | MAPTRAB9APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL13069950 | 0.75 | MAPT (0.54) | MAPTRAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL327800 | 0.74 | MAPT (0.57) | MAPTRAB9APOLBALDH1A1KDM4E | |
| SCHEMBL7790503 | 0.74 | MAPT (0.57) | MAPTRAB9APOLBALDH1A1KDM4E | |
| SCHEMBL24352865 | 0.74 | MAPT (0.57) | MAPTRAB9APOLBALDH1A1KDM4E | |
| SCHEMBL23731989 | 0.74 | MAPT (0.57) | MAPTRAB9APOLBALDH1A1KDM4E | |
| SCHEMBL18436831 | 0.74 | MAPT (0.57) | MAPTRAB9APOLBALDH1A1KDM4E | |
| SCHEMBL6132772 | 0.74 | GFER (0.59) | MAPTRAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6132774 | 0.74 | GFER (0.59) | MAPTRAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6132857 | 0.74 | USP2 (0.62) | MAPTRAB9APOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-B1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2008-02-20 | — | — | EP | disclosed |