SCHEMBL5036795

SCHEMBL5036795

Cc1cccnc1C=CCCNCCC=Cc1ncccc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.41
CYP2C19 P33261 2/20 0.41
CHRNB2 P17787 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA7 P36544 1/20 0.41
CHRNA4 P43681 1/20 0.41
MEN1 O00255 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX15 P16050 1/20 0.41
KMT2A Q03164 1/20 0.41
CTH P32929 2/20 0.39
NOS3 P29474 1/20 0.37
NOS1 P29475 1/20 0.37
NOS2 P35228 1/20 0.37
KDM4E B2RXH2 2/20 0.35
RAB9A P51151 2/20 0.35
NPC1 O15118 1/20 0.35
MAPT P10636 3/20 0.33
SCN8A Q9UQD0 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24440652 0.82 NOS3 (0.39) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA3
SCHEMBL22239425 0.78 NOS3 (0.42) CYP2D6CYP2C19MEN1KMT2ACTH
SCHEMBL24846577 0.78 NOS3 (0.36) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL7283316 0.75 NOS3 (0.39) CYP2D6CYP2C19CTHNOS3NOS1
Hydrochloric Acid SCHEMBL9872395 0.75 NOS3 (0.39) CYP2D6CYP2C19CTHNOS3NOS1
SCHEMBL20091037 0.74 NOS3 (0.45) MEN1KMT2ACTHNOS3NOS1
SCHEMBL7245280 0.74 NOS3 (0.45) MEN1KMT2ACTHNOS3NOS1
SCHEMBL9000307 0.74 NOS3 (0.45) CYP2D6MEN1ALOX15KMT2ACTH
SCHEMBL7245275 0.74 NOS3 (0.45) MEN1KMT2ACTHNOS3NOS1
SCHEMBL22834197 0.73 NOS3 (0.41) MEN1KMT2ACTHNOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615633-A4 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC (CA) 2008-07-09 EP disclosed
EP-1615633-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC. (CA) 2006-01-18 EP disclosed
WO-2004093817-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC. (CA) 2004-11-04 WO disclosed