Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203453 | 1.00 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3ATML3MBTL1 | |
| SCHEMBL10051069 | 0.81 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3EPHX1DPP4 | |
| SCHEMBL19003879 | 0.81 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3EPHX1DPP4 | |
| SCHEMBL10051066 | 0.81 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3EPHX1DPP4 | |
| Hydrochloric Acid SCHEMBL6589870 | 0.80 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3ATML3MBTL1 | |
| Aletamine SCHEMBL5038065 | 0.80 | EPHX1 (0.64) | SLC6A4SLC6A2SLC6A3EPHX1TAAR1 | |
| Aletamine SCHEMBL122065 | 0.80 | EPHX1 (0.64) | SLC6A4SLC6A2SLC6A3EPHX1TAAR1 | |
| Aletamine SCHEMBL122064 | 0.78 | EPHX1 (0.61) | SLC6A4SLC6A2SLC6A3EPHX1TAAR1 | |
| SCHEMBL12942876 | 0.77 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3ATML3MBTL1 | |
| SCHEMBL1779366 | 0.75 | SLC6A4 (0.78) | SLC6A4SLC6A2SLC6A3EPHX1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889903-A1 | Biocatalysts with amine acylase activity | Novartis AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| EP-0954571-B1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | NOVARTIS AG (CH) | 2007-08-29 | — | — | EP | disclosed |
| US-6235516-B1 | FROM RHODOCOCCUS GLOBERULUS, RHODOCOCCUS EQUI OR ARTHROBACTER AURESCENS | NOVARTIS AG (CH) | 2001-05-22 | — | — | US | disclosed |
| EP-0954571-A1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | Novartis AG (CH) | 1999-11-10 | — | — | EP | disclosed |
| WO-1997041214-A1 | BIOCATALYSTS WITH AMINE ACYLASE ACTIVITY | NOVARTIS AG (CH) | 1997-11-06 | — | — | WO | disclosed |