⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072971 | 0.77 | — | — | |
| Phosphonic Acid SCHEMBL7866708 | 0.74 | RNPEP (0.39) | — | |
| Phosphonic Acid SCHEMBL9705797 | 0.74 | RNPEP (0.39) | — | |
| SCHEMBL1890480 | 0.72 | — | — | |
| SCHEMBL579981 | 0.70 | — | — | |
| SCHEMBL9329975 | 0.69 | SLC7A5 (0.48) | — | |
| SCHEMBL9329977 | 0.69 | SLC7A5 (0.48) | — | |
| SCHEMBL8860012 | 0.69 | — | — | |
| Leucine SCHEMBL1191429 | 0.69 | SLC7A5 (0.82) | — | |
| Leucine SCHEMBL1191424 | 0.69 | SLC7A5 (0.82) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150125406-A1 | TOPICAL SKIN CARE COMPOSITION | JAFER LIMITED (VG) | 2015-05-07 | — | — | US | claimed |
| EP-0897717-B1 | Whitening skin cosmetic composition and melanogenic inhibitor agent containing such cosmetic composition | EXSYMOL SA (MC) | 2004-06-09 | — | — | EP | claimed |
| US-6280715-B1 | APPLYING AMINOORGANOPHOSPHONIC ACID OR -PHOSPHINIC ACID DERIVATIVE AND ORGANOSILICON COMPOUND | EXSYMOL S.A.M. (MC) | 2001-08-28 | — | — | US | claimed |
| JP-11092334-A | — | — | None | — | — | JP | disclosed |
| US-20150125406-A1 | TOPICAL SKIN CARE COMPOSITION | JAFER LIMITED (VG) | 2015-05-07 | — | — | US | disclosed |
| US-7345082-B2 | Phosphinic acids | HOFFMANN-LA ROCHE INC. (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |
| EP-1685142-A1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005044830-A1 | PHOSPHINIC ACIDS DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-19 | — | — | WO | disclosed |
| US-20050107341-A1 | Phosphinic acids | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-19 | — | — | US | disclosed |
| US-6737416-B2 | THROMBOLYTIC AGENT HAVING HIGHER SAFETY | MEIJI SEIKA KAISHA LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| US-20030119787-A1 | Phosphonic acid derivative having inhibitory activity against carboxypeptidase B | MEIJI SEIKA KAISHA LTD. (JP) | 2003-06-26 | — | — | US | disclosed |
| US-6576627-B1 | Such as 7-amino-2-((2-methyl-1-(3-phenylpropanoylamino)-propyl)hydroxyphosphinoyl) -methylheptanoic acid; thrombotic disease | MEIJI SEIKA KAISHA LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| EP-1152004-B1 | Phosphonic acid derivatives having carboxypeptidase B inhibitory action | MEIJI SEIKA KAISHA (JP) | 2003-05-07 | — | — | EP | disclosed |
| EP-1174434-A1 | Phosphonic acid derivative having inhibitory activity against carboxypeptidase B | MEIJI SEIKA KAISHA LTD. (JP) | 2002-01-23 | — | — | EP | disclosed |
| EP-1152004-A1 | PHOSPHONIC ACID DERIVATIVES HAVING CARBOXYPEPTIDASE B INHIBITORY ACTIVITY | MEIJI SEIKA KAISHA LTD. (JP) | 2001-11-07 | — | — | EP | disclosed |
| US-6280715-B1 | APPLYING AMINOORGANOPHOSPHONIC ACID OR -PHOSPHINIC ACID DERIVATIVE AND ORGANOSILICON COMPOUND | EXSYMOL S.A.M. (MC) | 2001-08-28 | — | — | US | disclosed |
| JP-H1192334-A | COSMETIC COMPOSITION ESPECIALLY USEFUL FOR WHITENING OF SKIN AND MELANOGENESIS-SUPPRESSING AGENT CONTAINING THE SAME COSMETIC COMPOSITION | EXSYMOL SAM | 1999-04-06 | — | — | JP | disclosed |
| WO-1997009333-A1 | NOVEL THIO-PHOSPHOORGANIC COMPOUNDS WITH PLANT PROTECTING ACTIVITY | SITRA FOUNDATION (FI) | 1997-03-13 | — | — | WO | disclosed |