Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | BCHE | P06276 | 5/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385523 | 0.93 | KDM4E (0.71) | KDM4EBCHETSHRTP53MAPT | |
| SCHEMBL5037311 | 0.92 | KDM4E (0.70) | KDM4EBCHETSHRMAPT | |
| SCHEMBL5037898 | 0.91 | KDM4E (0.62) | KDM4EBCHETP53SMN1; SMN2 | |
| SCHEMBL5041207 | 0.91 | KDM4E (0.65) | KDM4ETSHRTP53MAPTMEN1 | |
| SCHEMBL11890502 | 0.85 | KDM4E (0.73) | KDM4EBCHETSHRTP53MAPT | |
| SCHEMBL1387066 | 0.85 | KDM4E (0.80) | KDM4ETSHRMAPTALDH1A1HTT | |
| SCHEMBL1386481 | 0.83 | KDM4E (0.71) | KDM4EBCHETSHRTP53SMN1; SMN2 | |
| SCHEMBL1387031 | 0.83 | KDM4E (0.74) | KDM4ETSHRTP53MAPTALDH1A1 | |
| SCHEMBL5040662 | 0.83 | BCHE (0.63) | KDM4EBCHETSHRTP53MAPT | |
| SCHEMBL2579670 | 0.82 | KDM4E (0.66) | KDM4EBCHETSHRTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636215-B1 | FURAZANOBENZIMIDAZOLES | BASILEA PHARMACEUTICA AG (CH) | 2008-01-23 | — | — | EP | claimed |