Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037478 | 1.00 | GRM4 (0.53) | GRM4KDM4EALDH1A1CYP19A1MAOA | |
| SCHEMBL27605612 | 0.87 | GRM4 (0.46) | GRM4KDM4EALDH1A1CYP19A1MAOA | |
| SCHEMBL28798157 | 0.82 | MEN1 (0.54) | GRM4KDM4EALDH1A1CYP19A1MAOA | |
| SCHEMBL28773675 | 0.81 | HRH4 (0.58) | GRM4KDM4EALDH1A1CYP19A1MAOA | |
| SCHEMBL31484371 | 0.81 | HRH4 (0.58) | GRM4KDM4EALDH1A1CYP19A1MAOA | |
| SCHEMBL29432563 | 0.79 | NPC1 (0.55) | GRM4KDM4EALDH1A1CYP19A1MAOA | |
| SCHEMBL10123059 | 0.75 | GRM4 (0.56) | GRM4KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL10123058 | 0.75 | TTR (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL596715 | 0.75 | ALDH1A1 (0.46) | GRM4KDM4EALDH1A1CYP19A1MAOA | |
| SCHEMBL596716 | 0.75 | ALDH1A1 (0.46) | GRM4KDM4EALDH1A1CYP19A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928456-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS | Miikana Therapeutics, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007041358-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. (US) | 2007-04-12 | — | — | WO | disclosed |