Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 19/20 | 0.58 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039407 | 0.85 | KIF11 (0.54) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL5037659 | 0.84 | KIF11 (0.56) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL5037957 | 0.81 | KIF11 (0.62) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL5037656 | 0.78 | KIF11 (0.65) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL5113413 | 0.78 | KIF11 (0.76) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL5113407 | 0.78 | KIF11 (0.76) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL5751482 | 0.77 | KIF11 (0.57) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL6110928 | 0.77 | KIF11 (0.53) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL6110495 | 0.77 | KIF11 (0.54) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL5486903 | 0.77 | KIF11 (0.51) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680420-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-09-24 | — | — | EP | claimed |
| JP-2007510660-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1680420-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-19 | — | — | EP | claimed |
| WO-2005046588-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-05-26 | — | — | WO | claimed |