Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042994 | 0.89 | SLC6A2 (0.53) | TACR1HTR2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL5140305 | 0.88 | TACR1 (0.55) | TACR1HTR2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL1098050 | 0.83 | NR1H4 (0.40) | HTR2ACETPKDM1AHDAC8HDAC6 | |
| SCHEMBL7489022 | 0.82 | SLC6A4 (0.46) | TACR1HTR2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL5560496 | 0.82 | TACR1 (0.52) | TACR1HTR2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3668795 | 0.81 | SLC6A2 (0.43) | TACR1HTR2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL28392322 | 0.81 | SLC6A2 (0.46) | TACR1HTR2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL5399569 | 0.79 | TACR1 (0.48) | TACR1SLC6A2SLC6A3SLC6A4KCNH2 | |
| SCHEMBL1099406 | 0.79 | NR1H4 (0.40) | HTR2ACETPKDM1AHDAC8HDAC6 | |
| SCHEMBL28147768 | 0.78 | TACR1 (0.47) | TACR1HTR2ASLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622914-A4 | NEW PIPERIDINYLAMINO-THIENO 2,3-D PYRIMIDINE COMPOUNDS | EPIX DELAWARE INC (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1797099-A1 | PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS | Epix Delaware, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034511-A1 | PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS | EPIX DELAWARE, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| EP-1622914-A2 | NEW PIPERIDINYLAMINO-THIENO 2,3-D PYRIMIDINE COMPOUNDS | Predix Pharmaceuticals Holdings, Inc. (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004089312-A2 | NEW PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS | PREDIX PHARMACEUTICALS HOLDINGS, INC. (US) | 2004-10-21 | — | — | WO | disclosed |