Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | FNTA | P49354 | 3/20 | 0.40 |
| ▸ | FNTB | P49356 | 3/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140305 | 0.85 | TACR1 (0.55) | SLC6A2SLC6A4SLC6A3KCNH2TACR1 | |
| SCHEMBL28392322 | 0.85 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3HSD11B1KCNH2 | |
| SCHEMBL16654305 | 0.81 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3HSD11B1KCNH2 | |
| SCHEMBL5037801 | 0.81 | TACR1 (0.45) | SLC6A2SLC6A4SLC6A3KCNH2TACR1 | |
| SCHEMBL20791408 | 0.81 | SLC6A4 (0.57) | SLC6A2SLC6A4SLC6A3HSD11B1KCNH2 | |
| SCHEMBL25104099 | 0.80 | MAPKAPK2 (0.50) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL30929286 | 0.80 | MAPKAPK2 (0.50) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL10314189 | 0.80 | MAPKAPK2 (0.38) | SLC6A2SLC6A4SLC6A3HSD11B1KCNH2 | |
| SCHEMBL5042994 | 0.79 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3KCNH2TACR1 | |
| SCHEMBL5399569 | 0.79 | TACR1 (0.48) | SLC6A2SLC6A4SLC6A3HSD11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |