Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775809 | 0.89 | MAPT (0.54) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL3042603 | 0.88 | ALDH1A1 (0.54) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL16106421 | 0.84 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL5036825 | 0.83 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL3053531 | 0.78 | MAPT (0.66) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL4774886 | 0.77 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL27403161 | 0.77 | LRRK2 (0.52) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL4766240 | 0.76 | HIF1A (0.59) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL30501370 | 0.76 | NPC1 (0.65) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL20598315 | 0.76 | NPC1 (0.65) | MAPTMEN1KMT2AALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450796-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-1450796-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-01 | — | — | EP | disclosed |
| US-6596718-B1 | A compound of formula I has a good affinity to the A2A receptor and is useful for the treatment of diseases mediated by this receptor. | HOFFMANN-LA ROCHE INC. | 2003-07-22 | — | — | US | disclosed |
| WO-2003045385-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-05 | — | — | WO | disclosed |