Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | GPR3 | P46089 | 1/20 | 0.30 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257032 | 1.00 | GAA (0.36) | GAAMAPK1DRD2DRD4GPR3 | |
| SCHEMBL3524892 | 0.74 | KMT2A (0.47) | GAAMAPK1 | |
| SCHEMBL3524506 | 0.74 | ROCK1 (0.39) | DRD2DRD4 | |
| SCHEMBL3524505 | 0.74 | ROCK1 (0.39) | DRD2DRD4 | |
| SCHEMBL3524895 | 0.74 | KMT2A (0.47) | GAAMAPK1 | |
| SCHEMBL3524896 | 0.74 | KMT2A (0.47) | GAAMAPK1 | |
| SCHEMBL3524502 | 0.74 | ROCK1 (0.39) | DRD2DRD4 | |
| SCHEMBL3526076 | 0.73 | CHRM2 (0.46) | GAADRD2DRD4 | |
| SCHEMBL3526071 | 0.73 | CHRM2 (0.46) | GAADRD2DRD4 | |
| SCHEMBL3526073 | 0.73 | CHRM2 (0.46) | GAADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139533-A1 | SUBSTITUTED 4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139533-A1 | SUBSTITUTED 4-IMIDAZOLES | TAAR1, TAAR5, TACR1 | GAA 4000/4885MAPK1 951/4885DRD2 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.