Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426482 | 0.82 | HSD11B1 (0.34) | — | |
| SCHEMBL3427038 | 0.77 | HSD11B1 (0.45) | — | |
| SCHEMBL5662819 | 0.77 | HSD11B1 (0.33) | OPRM1OPRK1OPRL1 | |
| SCHEMBL5034230 | 0.76 | MEN1 (0.39) | — | |
| SCHEMBL13435198 | 0.75 | — | — | |
| SCHEMBL3427043 | 0.74 | — | — | |
| SCHEMBL13435167 | 0.67 | HSD11B1 (0.38) | — | |
| SCHEMBL14186140 | 0.66 | — | — | |
| SCHEMBL13435165 | 0.66 | HSD11B1 (0.61) | — | |
| SCHEMBL3426077 | 0.64 | HSD11B1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747198-B1 | ADAMANTYL PYRROLIDIN-2-ONE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-06-04 | — | — | EP | disclosed |