Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | QDPR | P09417 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22821271 | 0.87 | SLC6A4 (0.56) | SLC6A4DRD2CHRM1DRD1QDPR | |
| SCHEMBL29920020 | 0.84 | SLC6A4 (0.58) | SLC6A4QDPR | |
| SCHEMBL5010128 | 0.84 | SLC6A4 (0.48) | SLC6A4QDPR | |
| SCHEMBL22807055 | 0.84 | SLC6A4 (0.58) | SLC6A4QDPR | |
| SCHEMBL23372146 | 0.84 | SLC6A4 (0.48) | SLC6A4QDPR | |
| SCHEMBL24136831 | 0.81 | SLC6A4 (0.58) | SLC6A4DRD2CHRM1DRD1 | |
| SCHEMBL9731219 | 0.79 | SLC6A4 (0.46) | SLC6A4QDPR | |
| SCHEMBL10036370 | 0.79 | SLC6A4 (0.62) | SLC6A4 | |
| SCHEMBL30736527 | 0.79 | SLC6A4 (0.62) | SLC6A4 | |
| SCHEMBL13855399 | 0.78 | QDPR (0.44) | QDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-A4 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1622569-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Corporation (US) | 2006-02-08 | — | — | EP | claimed |
| WO-2004096139-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES | INCYTE CORPORATION (US) | 2004-11-11 | — | — | WO | claimed |