SCHEMBL5038853

SCHEMBL5038853

Cn1c(C(C)(C)C)c(-c2ccccc2)c2c(OCCCCCc3ccccc3)cccc2c1=O

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
S1PR5 Q9H228 1/20 0.37
ABCG2 Q9UNQ0 2/20 0.36
KCNA3 P22001 1/20 0.35
CYP1B1 Q16678 2/20 0.35
TACR1 P25103 3/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
PDE4A P27815 2/20 0.34
PDE4B Q07343 2/20 0.34
PDE4C Q08493 2/20 0.34
PDE4D Q08499 2/20 0.34
CYSLTR2 Q9NS75 1/20 0.34
CYSLTR1 Q9Y271 1/20 0.34
KMT2A Q03164 2/20 0.34
LMNA P02545 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1377878 0.82 KCNA5 (0.45) MAOAMAOB
SCHEMBL3098119 0.72 TACR1 (0.45) ABCG2TACR1L3MBTL1MAOAKMT2A
SCHEMBL1375552 0.68 KMT2A (0.49) CYP1B1TACR1TDP1L3MBTL1KMT2A
SCHEMBL3094005 0.64 KCNA5 (0.63) TACR1SMN1; SMN2
SCHEMBL9021233 0.64 TDP1 (0.59) CYP1B1TDP1L3MBTL1MAOBKMT2A
SCHEMBL30002666 0.62 CYP1A2 (0.46) KCNA3TDP1L3MBTL1
SCHEMBL8764977 0.62 CYSLTR2 (0.53) S1PR5L3MBTL1MAOAPDE4APDE4B
SCHEMBL9804792 0.62 CYSLTR2 (0.50) S1PR5CYSLTR2CYSLTR1
SCHEMBL10522502 0.62 MEN1 (0.43) KCNA3KMT2ALMNA
SCHEMBL3625058 0.61 TACR1 (0.46) TACR1L3MBTL1MAOAKMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1667982-A4 ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2008-08-13 EP disclosed
EP-1667982-A2 ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2006-06-14 EP disclosed
WO-2005030791-A2 ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2005-04-07 WO disclosed