Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 12/20 | 0.74 |
| ▸ | CHRM2 known ✓ | P08172 | 8/20 | 0.48 |
| ▸ | CHRM1 known ✓ | P11229 | 8/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5039534 | 1.00 | CHRM3 (0.74) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL141730 | 0.86 | CHRM3 (1.00) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL141731 | 0.86 | CHRM3 (1.00) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL4166137 | 0.81 | CHRM3 (0.88) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL4166138 | 0.81 | CHRM3 (0.88) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL3813744 | 0.80 | CHRM3 (0.72) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Iodide SCHEMBL3824617 | 0.74 | CHRM3 (0.66) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Iodide SCHEMBL4912619 | 0.74 | CHRM3 (0.66) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL143847 | 0.73 | CHRM3 (0.83) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL143848 | 0.73 | CHRM3 (0.83) | CHRM3CHRM2CHRM1APOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021231-A1 | Novel compounds | BIGGADIKE KEITH | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021231-A1 | Novel compounds | CYP8B1, PRMT8, CBR3 | CHRM3 17/4885CHRM2 51/4885CHRM1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.