Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.62 |
| ▸ | MMP2 | P08253 | 5/20 | 0.57 |
| ▸ | MMP12 | P39900 | 5/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6082024 | 0.96 | ADAM17 (0.58) | ADAM17MMP2MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL5035358 | 0.92 | ADAM17 (0.61) | ADAM17MMP2MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL5035194 | 0.86 | ADAM17 (0.53) | ADAM17MMP2MMP12MMP3 | |
| SCHEMBL5035209 | 0.84 | ADAM17 (0.51) | ADAM17MMP2MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL5035382 | 0.84 | ADAM17 (0.52) | ADAM17MMP2MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL5036738 | 0.83 | ADAM17 (0.52) | ADAM17MMP2MMP12 | |
| Trifluoroacetic Acid SCHEMBL5036460 | 0.83 | ADAM17 (0.54) | ADAM17MMP2 | |
| Trifluoroacetic Acid SCHEMBL5032737 | 0.82 | ADAM17 (0.53) | ADAM17MMP2 | |
| SCHEMBL5036461 | 0.81 | ADAM17 (0.53) | ADAM17MMP2 | |
| SCHEMBL5039526 | 0.79 | ADAM17 (0.50) | ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628974-A4 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1628974-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004108086-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-α CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-16 | — | — | WO | disclosed |