Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 17/20 | 0.53 |
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP3 | P08254 | 3/20 | 0.44 |
| ▸ | ADAM33 | Q9BZ11 | 2/20 | 0.44 |
| ▸ | MMP7 | P09237 | 2/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | MMP15 | P51511 | 1/20 | 0.43 |
| ▸ | MMP16 | P51512 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039639 | 0.86 | ADAM17 (0.53) | ADAM17MMP13MMP2MMP9MMP3 | |
| SCHEMBL5036698 | 0.82 | ADAM17 (0.47) | ADAM17MMP13MMP2MMP9MMP3 | |
| SCHEMBL5041676 | 0.82 | ADAM17 (0.54) | ADAM17MMP13MMP2MMP9MMP3 | |
| SCHEMBL5035407 | 0.79 | ADAM17 (0.48) | ADAM17MMP13MMP2MMP9MMP3 | |
| Trifluoroacetic Acid SCHEMBL5032789 | 0.78 | ADAM17 (0.55) | ADAM17MMP13MMP2MMP9 | |
| SCHEMBL5041757 | 0.76 | ADAM17 (0.45) | ADAM17MMP13MMP2MMP9MMP3 | |
| SCHEMBL6023353 | 0.74 | ADAM17 (0.57) | ADAM17MMP13MMP3MMP7ADAMTS4 | |
| SCHEMBL6023092 | 0.72 | ADAM17 (0.47) | ADAM17MMP13MMP2MMP3ADAM33 | |
| SCHEMBL6318995 | 0.70 | ADAM17 (1.00) | ADAM17MMP13MMP2MMP9 | |
| SCHEMBL5041747 | 0.69 | ADAM17 (0.49) | ADAM17MMP13MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628974-A4 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1628974-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004108086-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-α CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-16 | — | — | WO | disclosed |