Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NAAA | Q02083 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | MLYCD | O95822 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039808 | 0.89 | GAA (0.56) | NPC1RAB9AHDAC6SIGMAR1SMN1; SMN2 | |
| SCHEMBL9967364 | 0.88 | NPC1 (0.88) | NPC1RAB9AHDAC6HPGDSMN1; SMN2 | |
| SCHEMBL5694328 | 0.88 | NPC1 (0.88) | NPC1RAB9AHDAC6HPGDSMN1; SMN2 | |
| SCHEMBL24420725 | 0.88 | NPC1 (0.88) | NPC1RAB9AHDAC6HPGDSMN1; SMN2 | |
| SCHEMBL4728815 | 0.88 | NPC1 (0.88) | NPC1RAB9AHDAC6HPGDSMN1; SMN2 | |
| SCHEMBL5044268 | 0.87 | NAAA (0.60) | NPC1RAB9ASIGMAR1HPGDL3MBTL1 | |
| SCHEMBL13577912 | 0.87 | NPC1 (0.84) | NPC1RAB9AHDAC6HPGDSMN1; SMN2 | |
| SCHEMBL1853750 | 0.86 | NPC1 (0.62) | NPC1RAB9AHDAC6SIGMAR1HPGD | |
| SCHEMBL5044615 | 0.86 | TMEM97 (0.60) | SIGMAR1SMN1; SMN2L3MBTL1NAAAMLYCD | |
| SCHEMBL27619622 | 0.85 | NPC1 (0.72) | NPC1RAB9AHDAC6HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |