Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 18/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27648851 | 0.86 | SLC6A9 (0.70) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5038162 | 0.86 | SLC6A9 (0.78) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5041137 | 0.86 | SLC6A9 (0.56) | SLC6A9KCNH2SLC6A5PKMSLC6A7 | |
| SCHEMBL5037851 | 0.84 | SLC6A9 (0.81) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5042096 | 0.84 | SLC6A9 (0.71) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5041696 | 0.84 | SLC6A9 (0.75) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL4433387 | 0.82 | SLC6A9 (1.00) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5042973 | 0.81 | SLC6A9 (0.78) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL2825571 | 0.81 | SLC6A9 (0.69) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL2825448 | 0.81 | SLC6A9 (0.69) | SLC6A9KCNH2SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |