Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | IDH2 | P48735 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035035 | 0.93 | MAPK1 (0.55) | EPHX2MAPK1KMT2AKDM4EHTT | |
| SCHEMBL5035073 | 0.93 | KMT2A (0.49) | EPHX2MAPK1KMT2AKDM4EHTT | |
| SCHEMBL5039201 | 0.91 | MAPK1 (0.69) | EPHX2MAPK1KMT2AKDM4EHTT | |
| SCHEMBL5132933 | 0.91 | MAPK1 (0.53) | EPHX2MAPK1KMT2AKDM4EHTT | |
| SCHEMBL5032689 | 0.89 | KMT2A (0.52) | EPHX2MAPK1KMT2AKDM4EHTT | |
| SCHEMBL5032644 | 0.89 | KMT2A (0.52) | EPHX2MAPK1KMT2AKDM4EHTT | |
| SCHEMBL5049794 | 0.89 | MAPK1 (0.72) | EPHX2MAPK1KMT2AKDM4EHTT | |
| SCHEMBL5035279 | 0.88 | HPGD (0.46) | MAPK1KMT2AKDM4EHTTHPGD | |
| SCHEMBL5035013 | 0.88 | KDM4E (0.46) | MAPK1KMT2AKDM4EHTTHPGD | |
| SCHEMBL5039162 | 0.88 | CA12 (0.47) | MAPK1KDM4EHPGDTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |