Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032671 | 0.91 | MAPK1 (0.71) | MAPK1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL5041463 | 0.91 | EPHX2 (0.57) | MAPK1KMT2AKDM4EHTTEPHX2 | |
| SCHEMBL5047758 | 0.90 | MAPK1 (0.85) | MAPK1KMT2AKDM4EHTTEPHX2 | |
| SCHEMBL5041469 | 0.90 | KMT2A (0.63) | MAPK1KMT2AKDM4EHTTEPHX2 | |
| SCHEMBL5039222 | 0.89 | MAPK1 (0.68) | MAPK1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL5035253 | 0.89 | MAPK1 (0.52) | MAPK1KMT2AKDM4EHTTEPHX2 | |
| SCHEMBL5034992 | 0.89 | MAPK1 (0.52) | MAPK1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL5039150 | 0.89 | KDM4E (0.54) | MAPK1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL5035072 | 0.87 | KDM4E (0.54) | MAPK1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL5036183 | 0.87 | KMT2A (0.52) | MAPK1KMT2AKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |