Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP17 | Q9ULZ9 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041772 | 0.82 | ADAM17 (0.52) | ADAM17MMP2MMP3 | |
| SCHEMBL5032760 | 0.81 | ADAM17 (0.42) | ADAM17MMP13MMP2 | |
| SCHEMBL5036434 | 0.80 | ADAM17 (0.48) | ADAM17MMP13MMP2MMP9 | |
| SCHEMBL5032757 | 0.76 | ADAM17 (0.43) | ADAM17MMP13MMP2MMP3MMP9 | |
| SCHEMBL5036449 | 0.75 | ADAM17 (0.48) | ADAM17MMP13MMP2MMP3MMP17 | |
| SCHEMBL4058393 | 0.73 | ADAM17 (0.60) | ADAM17MMP13MMP2MMP3 | |
| SCHEMBL6632245 | 0.73 | ADAM17 (0.63) | ADAM17MMP13MMP2MMP3 | |
| Trifluoroacetic Acid SCHEMBL5041588 | 0.73 | ADAM17 (0.53) | ADAM17MMP13MMP2MMP9 | |
| SCHEMBL1366484 | 0.72 | ADAM17 (0.60) | ADAM17MMP13MMP2MMP3 | |
| SCHEMBL8353322 | 0.72 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628974-A4 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1628974-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME (TACE) | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004108086-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF TUMOR NECROSIS FACTOR-α CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-16 | — | — | WO | disclosed |