Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 11/20 | 0.59 |
| ▸ | SLC6A5 | Q9Y345 | 6/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133872 | 0.90 | SLC6A9 (0.59) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL5133355 | 0.89 | SLC6A9 (0.58) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL5042592 | 0.89 | SLC6A9 (0.58) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL4419697 | 0.89 | SLC6A9 (0.61) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL27669124 | 0.88 | SLC6A9 (0.56) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL4420325 | 0.88 | SLC6A9 (0.73) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL5045633 | 0.88 | SLC6A9 (0.61) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL5037824 | 0.87 | SLC6A9 (0.56) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL5048170 | 0.87 | SLC6A9 (0.56) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 | |
| SCHEMBL5132694 | 0.86 | SLC6A9 (0.57) | SLC6A9SLC6A5ENPP2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |