Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 11/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 10/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036395 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2ENPP3ENPP1ENPP2NPC1 | |
| SCHEMBL5036049 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2ENPP3ENPP1ENPP2NPC1 | |
| SCHEMBL5033795 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2ENPP3ENPP1ENPP2NPC1 | |
| SCHEMBL5036123 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2ENPP3ENPP1ENPP2MAPT | |
| SCHEMBL5036237 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2ENPP3ENPP1ENPP2NPC1 | |
| SCHEMBL5036041 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2ENPP3ENPP1ENPP2MAPT | |
| SCHEMBL5037714 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2ENPP3ENPP1ENPP2NPC1 | |
| SCHEMBL5036520 | 0.83 | KMT2A (0.50) | SMN1; SMN2ENPP3ENPP1ENPP2MAPT | |
| SCHEMBL5042988 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2ENPP3ENPP1ENPP2NPC1 | |
| SCHEMBL5041061 | 0.83 | ENPP3 (0.39) | SMN1; SMN2ENPP3ENPP1ENPP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-B1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2008-02-20 | — | — | EP | disclosed |
| US-7041668-B2 | Substituted benzimidazole compounds and their use for the treatment of cancer | AVENTIS PHARMA S.A. (FR) | 2006-05-09 | — | — | US | disclosed |
| US-20050014811-A1 | Substituted benzimidazole compounds and their use for the treatment of cancer | AVENTIS PHARMA S.A. (FR) | 2005-01-20 | — | — | US | disclosed |
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014811-A1 | Substituted benzimidazole compounds and their use for the treatment of cancer | CDKL3, CCNL2, CDKL1 | SMN1; SMN2 2426/4885ENPP3 2927/4885ENPP1 3915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.