Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 7/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047891 | 0.93 | PTGER2 (0.52) | KMT2ATAS2R14PTGER2MEN1HTT | |
| SCHEMBL5043219 | 0.90 | TAS2R14 (0.45) | KMT2ATAS2R14PTGER2MEP1BMEN1 | |
| SCHEMBL5043600 | 0.83 | PTGER2 (0.49) | KMT2ATAS2R14PTGER2MEN1PTGES | |
| SCHEMBL5043270 | 0.78 | TAS2R14 (0.64) | KMT2ATAS2R14MEP1BMEN1PTGES | |
| SCHEMBL5043143 | 0.76 | KMT2A (0.51) | KMT2ATAS2R14MEP1B | |
| SCHEMBL5725296 | 0.74 | PTGER2 (0.45) | KMT2APTGER2MEN1 | |
| SCHEMBL4943463 | 0.74 | PTGER2 (0.69) | PTGER2 | |
| SCHEMBL5043193 | 0.74 | TAS2R14 (0.56) | KMT2ATAS2R14MEP1BMEN1CNR2 | |
| SCHEMBL27509041 | 0.72 | TAS2R14 (0.62) | KMT2ATAS2R14MEP1BMEN1HTT | |
| SCHEMBL8211693 | 0.72 | PTGER2 (0.46) | KMT2ATAS2R14PTGER2MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |