⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18169700 | 1.00 | — | — | |
| SCHEMBL18169960 | 1.00 | — | — | |
| SCHEMBL455138 | 0.91 | — | — | |
| SCHEMBL18169999 | 0.91 | — | — | |
| SCHEMBL18169897 | 0.91 | — | — | |
| SCHEMBL1040029 | 0.89 | EPHX1 (0.33) | — | |
| SCHEMBL385302 | 0.87 | — | — | |
| SCHEMBL5596824 | 0.81 | — | — | |
| SCHEMBL23361656 | 0.81 | — | — | |
| SCHEMBL3678284 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113750094-A | Pyrazole compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2021-12-07 | — | — | CN | claimed |
| CN-107438603-B | Pyrazole compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2021-08-10 | — | — | CN | claimed |
| EP-3286181-B1 | PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | RIGEL PHARMACEUTICALS INC (US) | 2021-01-27 | — | — | EP | claimed |
| EP-3286181-A1 | PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | Rigel Pharmaceuticals, Inc. (US) | 2018-02-28 | — | — | EP | claimed |
| WO-2016172560-A1 | PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | RIGEL PHARMACEUTICALS, INC. (US) | 2016-10-27 | — | — | WO | claimed |
| US-11370808-B2 | Pyrazole compounds and methods for making and using the compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2022-06-28 | — | — | US | disclosed |
| CN-113750094-A | Pyrazole compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-107438603-B | Pyrazole compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2021-08-10 | — | — | CN | disclosed |
| EP-3286181-B1 | PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | RIGEL PHARMACEUTICALS INC (US) | 2021-01-27 | — | — | EP | disclosed |
| US-20190153006-A1 | PYRAZOLE COMPOUNDS AND METHODS FOR MAKING AND USING THE COMPOUNDS | RIGEL PHARMACEUTICALS, INC. (US) | 2019-05-23 | — | — | US | disclosed |
| US-10208075-B2 | Pyrazole compounds and method for making and using the compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2019-02-19 | — | — | US | disclosed |
| US-10208074-B2 | Pyrazole compounds and method for making and using the compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2019-02-19 | — | — | US | disclosed |
| US-4968802-A | ESTERIFICATION WITH ALKOXYCYCLOALKYL SULFONATE | ELI LILLY AND COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| US-4914100-A | TREATING THROMBOSIS | ELI LILLY AND COMPANY (US) | 1990-04-03 | — | — | US | disclosed |
| US-4847261-A | ANALGESICS, HYPOTENSIVES | ELI LILLY AND COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0320006-A2 | Uses of 1,4-dihydropyridines | LABORATOIRES SYNTEX (FR) | 1989-06-14 | — | — | EP | disclosed |
| US-4761420-A | CARDIOVASCULAR DISORDERS | LABORATOIRES SYNTEX S.A. (FR) | 1988-08-02 | — | — | US | disclosed |
| US-4714704-A | Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists | ELI LILLY AND COMPANY (US) | 1987-12-22 | — | — | US | disclosed |
| EP-0249245-A2 | Antihypertensive dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1987-12-16 | — | — | EP | disclosed |
| EP-0219257-A2 | Esters of dihydrolysergic acid | ELI LILLY AND COMPANY (US) | 1987-04-22 | — | — | EP | disclosed |