Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421793 | 0.77 | GRM5 (0.46) | GRM5MAOBMAOAMAP4K1BUB1 | |
| SCHEMBL23657094 | 0.76 | GRM5 (0.67) | GRM5MAOBMAOAMAP4K1PIM1 | |
| SCHEMBL4429541 | 0.76 | GRM5 (0.44) | GRM5MAOBMAOAMAP4K1NPC1 | |
| SCHEMBL4433324 | 0.75 | GRM5 (0.54) | GRM5MAOBMAOAMAP4K1NPC1 | |
| SCHEMBL4420891 | 0.71 | AAK1 (0.46) | GRM5MAOBMAOACYP1A2CYP3A4 | |
| SCHEMBL5043735 | 0.70 | GRM5 (0.41) | GRM5MAOBMAOAMAP4K1PIM1 | |
| SCHEMBL4429787 | 0.69 | GRM5 (0.40) | GRM5MAOBMAOAMAP4K1NPC1 | |
| SCHEMBL4423765 | 0.69 | BRAF (0.41) | GRM5MAOBMAOAMAP4K1TSHR | |
| SCHEMBL936485 | 0.66 | MAOA (0.48) | GRM5MAOBMAOANPC1RAB9A | |
| SCHEMBL9955702 | 0.65 | GRM5 (1.00) | GRM5MAOBMAOANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | claimed |