Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 5/20 | 0.34 |
| ▸ | PPARA | Q07869 | 5/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP12 | P39900 | 3/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044443 | 0.90 | ALDH1A1 (0.39) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL1853892 | 0.82 | SPHK1 (0.49) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL1854246 | 0.82 | SPHK1 (0.49) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5039515 | 0.82 | SPHK1 (0.42) | SPHK1PPARGPPARAS1PR1S1PR5 | |
| SCHEMBL5043973 | 0.82 | SPHK1 (0.45) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5039859 | 0.81 | PPARG (0.41) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5041065 | 0.80 | SPHK1 (0.42) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6806239 | 0.80 | SPHK1 (0.42) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5040963 | 0.79 | KDM4E (0.42) | SPHK1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6024036 | 0.78 | SPHK1 (0.40) | SPHK1NPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | claimed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | claimed |