Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043921 | 0.91 | KLKB1 (0.52) | ALDH1A1PPARGKLKB1POLBCNR1 | |
| SCHEMBL5044134 | 0.88 | CHRM1 (0.45) | ALDH1A1PPARGCHRM1CNR1CNR2 | |
| SCHEMBL5048566 | 0.87 | KMT2A (0.44) | ALDH1A1PPARGKLKB1POLBCHRM1 | |
| SCHEMBL5043784 | 0.87 | ALDH1A1 (0.44) | ALDH1A1PPARGCHRM1NPC1P2RX7 | |
| SCHEMBL5048580 | 0.86 | CHRM1 (0.44) | PPARGCHRM1CNR1EIF4ECNR2 | |
| SCHEMBL5048709 | 0.85 | HPGD (0.45) | ALDH1A1PPARGKLKB1POLBEIF4E | |
| SCHEMBL5049089 | 0.85 | HPGD (0.44) | ALDH1A1KLKB1EIF4ENPC1KMT2A | |
| SCHEMBL5043975 | 0.84 | KLKB1 (0.46) | ALDH1A1KLKB1POLBEIF4EKLK1 | |
| SCHEMBL5047596 | 0.84 | KLKB1 (0.49) | ALDH1A1KLKB1POLBKLK1NPC1 | |
| SCHEMBL5048619 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KLKB1POLBKLK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622573-A4 | MOLECULES ENHANCING DERMAL DELIVERY OF INFLUENZA VACCINES | BECTON DICKINSON CO (US) | 2008-09-10 | — | — | EP | disclosed |
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-7135488-B2 | Pyrrolyl-thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-14 | — | — | US | disclosed |
| EP-1622573-A2 | MOLECULES ENHANCING DERMAL DELIVERY OF INFLUENZA VACCINES | Becton, Dickinson and Company (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1583762-A1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2005016239-A2 | MOLECULES ENHANCING DERMAL DELIVERY OF INFLUENZA VACCINES | BECTON DICKINSON AND COMPANY (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
| WO-2004060888-A1 | NOVEL CB 1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | ALDH1A1 959/4885PPARG 103/4885KLKB1 3949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.