Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039339 | 0.92 | AURKA (0.62) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL2049861 | 0.91 | AURKA (0.67) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL3424451 | 0.90 | AURKA (0.66) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL2049238 | 0.87 | AURKA (0.64) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL3432058 | 0.87 | AURKA (0.79) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL6024573 | 0.86 | AURKA (0.74) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL5039292 | 0.86 | AURKA (0.74) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL6089265 | 0.86 | AURKA (0.73) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL6027367 | 0.86 | AURKA (0.73) | AURKAAURKBPDGFRBPDGFRACSF1R | |
| SCHEMBL3427437 | 0.81 | AURKA (0.67) | AURKAAURKBPDGFRBPDGFRACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | claimed |