Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.60 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | MST1R | Q04912 | 2/20 | 0.47 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039292 | 1.00 | AURKA (0.74) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL6027367 | 0.90 | AURKA (0.73) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL6089265 | 0.90 | AURKA (0.73) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL5043450 | 0.89 | AURKA (0.76) | AURKAAURKBKDRPDGFRBFLT4 | |
| SCHEMBL5039248 | 0.89 | AURKA (0.74) | AURKAAURKBPDGFRBPDGFRAKIT | |
| SCHEMBL3432058 | 0.89 | AURKA (0.79) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL2049861 | 0.87 | AURKA (0.67) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3424451 | 0.87 | AURKA (0.66) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL5044572 | 0.86 | AURKA (0.66) | AURKAAURKBKDRPDGFRBPDGFRA | |
| SCHEMBL3488439 | 0.85 | AURKA (1.00) | AURKAAURKBKDRPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635837-A1 | (3-((QUINAZOLIN-4-YL)AMINO)-1H-PYRAZOL-1-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS AURORA KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004105764-A1 | (3- ((QUINAZOLIN-4-YL) AMINO )-1H-PYRAZOL-1-YL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS AURORA KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |