SCHEMBL5044586

SCHEMBL5044586

CCCCNC(=O)c1cc(-c2csc(-c3ccc(OC)cc3)n2)n(CC2CCCO2)c1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25A P30304 1/20 0.59
CDC25B P30305 1/20 0.59
CDC25C P30307 1/20 0.59
DUSP3 P51452 1/20 0.59
ALDH1A1 P00352 12/20 0.46
HPGD P15428 4/20 0.46
KDM4E B2RXH2 6/20 0.45
KMT2A Q03164 6/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
GLA P06280 1/20 0.45
PKM P14618 1/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
KLKB1 P03952 1/20 0.45
GAA P10253 3/20 0.45
MAPT P10636 3/20 0.44
TP53 P04637 1/20 0.44
TSHR P16473 5/20 0.43
HTT P42858 4/20 0.43
CASP1 P29466 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5039512 0.90 CDC25A (0.61) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5043875 0.89 ALDH1A1 (0.47) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5047146 0.88 CDC25A (0.45) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5043800 0.88 CDC25A (0.44) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5048712 0.88 CDC25A (0.59) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5046853 0.88 CDC25A (0.59) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5044320 0.87 CDC25A (0.67) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5043937 0.87 CDC25A (0.59) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5048559 0.87 ALDH1A1 (0.47) CDC25ACDC25BCDC25CDUSP3ALDH1A1
SCHEMBL5044520 0.86 ALDH1A1 (0.45) CDC25ACDC25BCDC25CDUSP3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1583762-B1 PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP disclosed
US-7135488-B2 Pyrrolyl-thiazole derivatives HOFFMANN-LA ROCHE INC. (US) 2006-11-14 US disclosed
EP-1583762-A1 PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-10-12 EP disclosed
WO-2004060888-A1 NOVEL CB 1 RECEPTOR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2004-07-22 WO disclosed