Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029854 | 0.83 | GPR119 (0.50) | KCNH2GPR119 | |
| SCHEMBL5038361 | 0.82 | KCNH2 (0.43) | KCNH2OPRK1GPR119SLC6A2SLC6A3 | |
| SCHEMBL20958488 | 0.78 | KCNH2 (0.46) | KCNH2OPRK1HTR3EHTR3BHTR3A | |
| SCHEMBL20958487 | 0.78 | KCNH2 (0.46) | KCNH2OPRK1HTR3EHTR3BHTR3A | |
| SCHEMBL20958489 | 0.78 | KCNH2 (0.46) | KCNH2OPRK1HTR3EHTR3BHTR3A | |
| SCHEMBL12076980 | 0.75 | KCNH2 (0.51) | KCNH2OPRK1GPR119LMNACYP2D6 | |
| SCHEMBL12076981 | 0.75 | KCNH2 (0.51) | KCNH2OPRK1GPR119LMNACYP2D6 | |
| SCHEMBL25173818 | 0.75 | KCNH2 (0.38) | KCNH2OPRK1GPR119LMNACYP2D6 | |
| SCHEMBL20958512 | 0.75 | KCNH2 (0.38) | KCNH2OPRK1GPR119SLC6A2SLC6A3 | |
| SCHEMBL25173819 | 0.75 | KCNH2 (0.38) | KCNH2OPRK1GPR119LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957493-A1 | 8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS | N.V. Organon (NL) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007063071-A1 | 8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS | N.V. ORGANON (NL) | 2007-06-07 | — | — | WO | disclosed |