Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.47 |
| ▸ | HTR2C | P28335 | 12/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048649 | 0.91 | IDH1 (0.49) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL5046011 | 0.91 | HTR2A (0.48) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL5039474 | 0.88 | NPC1 (0.43) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL6883123 | 0.88 | EIF4E (0.46) | HPGDIDH1ALDH1A1LMNA | |
| SCHEMBL5039399 | 0.88 | KLKB1 (0.41) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL5043824 | 0.87 | MEN1 (0.43) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL5049089 | 0.87 | HPGD (0.44) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL5047822 | 0.87 | HTR2A (0.51) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL5043863 | 0.85 | TNK2 (0.42) | HTR2AHTR2CSLC6A4KCNH2HPGD | |
| SCHEMBL5049135 | 0.81 | ALDH1A1 (0.60) | HTR2AHTR2CSLC6A4HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-7135488-B2 | Pyrrolyl-thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-14 | — | — | US | disclosed |
| EP-1583762-A1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060888-A1 | NOVEL CB 1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |