Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537029 | 0.76 | KDM4E (0.37) | — | |
| SCHEMBL3547593 | 0.73 | ALDH1A1 (0.32) | MAOA | |
| SCHEMBL5584244 | 0.73 | KDM4E (0.44) | — | |
| SCHEMBL3543903 | 0.68 | SLC2A1 (0.40) | — | |
| SCHEMBL5584724 | 0.65 | CYP19A1 (0.40) | — | |
| SCHEMBL146614 | 0.63 | ALDH1A1 (0.39) | — | |
| SCHEMBL30968870 | 0.63 | ALDH1A1 (0.39) | — | |
| SCHEMBL13019332 | 0.63 | SCN4A (0.36) | MAOA | |
| SCHEMBL5035228 | 0.61 | AHR (0.39) | MAOA | |
| SCHEMBL30192941 | 0.60 | ALDH1A1 (0.45) | MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-A4 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1622569-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Corporation (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096139-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES | INCYTE CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |