⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28691115 | 0.88 | — | — | |
| SCHEMBL8532055 | 0.67 | THRB (0.32) | — | |
| SCHEMBL6362966 | 0.67 | — | — | |
| SCHEMBL14361050 | 0.67 | — | — | |
| SCHEMBL31473651 | 0.66 | — | — | |
| Hydrogen Sulfide SCHEMBL29062317 | 0.65 | THRB (0.30) | — | |
| SCHEMBL8373078 | 0.65 | — | — | |
| SCHEMBL29102395 | 0.63 | — | — | |
| SCHEMBL4024768 | 0.62 | — | — | |
| SCHEMBL1496435 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |
| EP-1362843-B1 | N-cyclopropyl-2-difluoromethoxy-3-bromoaniline and intermediate used for production thereof | IHARA CHEMICAL IND CO (JP) | 2006-06-14 | — | — | EP | disclosed |
| EP-1031555-B1 | DIFLUOROMETHOXYBENZENE DERIVATIVES AND THEIR USE AS INTERMEDIATES | IHARA CHEMICAL IND CO (JP) | 2005-04-13 | — | — | EP | disclosed |
| EP-0990639-B1 | PROCESS FOR PRODUCING N-CYCLOPROPYLANILINES AND INTERMEDIATES USED THEREFOR | IHARA CHEMICAL IND CO (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1362843-A2 | N-cyclopropyl-2-difluoromethoxy-3-halogenoaniline and intermediate used for production thereof | Ihara Chemical Industry Co., Ltd. (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-6316658-B1 | QUINOLONE CARBOXYLATE CHEMICAL INTERMEDIATES; MICROBIOCIDES, BACTERICIDES | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6162944-A | Process for production of N-cyclopropylanilines and intermediates therefor | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2000-12-19 | — | — | US | disclosed |
| EP-1031555-A1 | N-CYCLOPROPYL-2-DIFLUOROMETHOXY-3-HALOGENOANILINES AND INTERMEDIATES FOR THE PREPARATION THEREOF | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2000-08-30 | — | — | EP | disclosed |
| EP-0990639-A1 | PROCESS FOR PRODUCING N-CYCLOPROPYLANILINES AND INTERMEDIATES USED THEREFOR | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2000-04-05 | — | — | EP | disclosed |
| US-5866589-A | Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds | PHARMACIA & UPJOHN COMPANY (US) | 1999-02-02 | — | — | US | disclosed |
| US-5426179-A | Substituted androstanes | ZAMBON GROUP S.P.A. (IT) | 1995-06-20 | — | — | US | disclosed |
| WO-1995002573-A2 | NEW METHOD FOR N-CYCLOPROPYLATION OF AROMATIC AMINES, AS WELL AS COMPOUNDS AND COMPOSITIONS OBTAINED | SOMFAI EVA (HU) | 1995-01-26 | — | — | WO | disclosed |
| US-5233091-A | Cyclopropyl fluoroaniline as chemical intermediate for bactericides | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0499327-A1 | Steroid compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1992-08-19 | — | — | EP | disclosed |
| US-5104868-A | Bactericides | PFIZER INC. (US) | 1992-04-14 | — | — | US | disclosed |
| US-5103040-A | Bactericides | PFIZER INC. (US) | 1992-04-07 | — | — | US | disclosed |
| US-5039682-A | Bactericides | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0348088-A1 | 6-Fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor | PFIZER INC. (US) | 1989-12-27 | — | — | EP | disclosed |
| EP-0332930-A2 | Process for the synthesis of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives | BAYER AG (DE) | 1989-09-20 | — | — | EP | disclosed |
| EP-0332033-A2 | N-cyclopropyl anilines and their use in processes for the synthesis of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives | BAYER AG (DE) | 1989-09-13 | — | — | EP | disclosed |