SCHEMBL5045271

SCHEMBL5045271

Nc1nnnc2c3ncccc3c3ccccc3c12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.43
HSP90AA1 P07900 4/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
NPC1 O15118 1/20 0.40
HSP90AB1 P08238 2/20 0.38
IDO1 P14902 1/20 0.38
PSMB5 P28074 1/20 0.38
ALDH1A1 P00352 3/20 0.37
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
APAF1 O14727 1/20 0.37
TDP2 O95551 1/20 0.37
MAPT P10636 1/20 0.37
CASP3 P42574 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
KDM4E B2RXH2 2/20 0.36
PARP1 P09874 3/20 0.36
TYMS P04818 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31186251 0.76 L3MBTL1 (0.50) DHFRHSP90AA1L3MBTL1NPC1HSP90AB1
SCHEMBL4993117 0.75 HSP90AA1 (0.64) DHFRHSP90AA1L3MBTL1NPC1HSP90AB1
SCHEMBL21298321 0.73 HSP90AA1 (0.50) HSP90AA1L3MBTL1NPC1HSP90AB1IDO1
SCHEMBL21298320 0.72 HSP90AA1 (0.48) HSP90AA1L3MBTL1NPC1HSP90AB1IDO1
SCHEMBL18057742 0.72 HSP90AA1 (0.46) DHFRHSP90AA1L3MBTL1NPC1HSP90AB1
SCHEMBL422507 0.71 HSP90AA1 (0.56) HSP90AA1L3MBTL1NPC1HSP90AB1IDO1
SCHEMBL30733943 0.71 HSP90AA1 (0.56) HSP90AA1L3MBTL1NPC1HSP90AB1IDO1
SCHEMBL17523388 0.71 HSP90AA1 (0.64) DHFRHSP90AA1L3MBTL1NPC1HSP90AB1
SCHEMBL15374722 0.71 HSP90AA1 (0.56) HSP90AA1L3MBTL1NPC1HSP90AB1IDO1
SCHEMBL21298316 0.70 HSP90AA1 (0.52) DHFRHSP90AA1L3MBTL1NPC1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019401-B1 COMPLEX COMPRISING A RARE-EARTH METAL ION AND A COMPLEXING MOIETY KONINKL PHILIPS ELECTRONICS NV (NL) 2008-01-16 EP disclosed
EP-1019401-A1 COMPLEX COMPRISING A RARE-EARTH METAL ION AND A COMPLEXING MOIETY Akzo Nobel N.V. (NL) 2000-07-19 EP disclosed
WO-1998049163-A1 COMPLEX COMPRISING A RARE-EARTH METAL ION AND A COMPLEXING MOIETY AKZO NOBEL N.V. (NL) 1998-11-05 WO disclosed