Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423409 | 1.00 | KDM1A (0.40) | KDM1AMAOBGPR119PDE4BMAP4K4 | |
| SCHEMBL4421925 | 0.91 | KDM1A (0.40) | KDM1AMAOBGPR119PDE4BMAP4K4 | |
| SCHEMBL5040392 | 0.88 | MAOB (0.45) | KDM1AMAOBPDE4BMAP4K4GAK | |
| SCHEMBL4421425 | 0.88 | MAOB (0.45) | KDM1AMAOBPDE4BMAP4K4GAK | |
| SCHEMBL5040390 | 0.88 | MAOB (0.45) | KDM1AMAOBPDE4BMAP4K4GAK | |
| SCHEMBL4433213 | 0.79 | CYP24A1 (0.43) | KDM1AMAOBGPR119PDE4BGSK3A | |
| SCHEMBL4432725 | 0.79 | CYP19A1 (0.40) | GSK3AGSK3BTP53CYP19A1ALDH1A1 | |
| SCHEMBL4430429 | 0.78 | ALDH1A1 (0.38) | GPR119MAPTCYP19A1ALDH1A1HPGD | |
| SCHEMBL4421876 | 0.76 | MAOB (0.40) | KDM1AMAOBPDE4BMAP4K4GAK | |
| SCHEMBL4420235 | 0.73 | CYP24A1 (0.42) | MAOBPDE4BGSK3AGSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | claimed |