Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 9/20 | 0.53 |
| ▸ | CA1 | P00915 | 9/20 | 0.53 |
| ▸ | CA2 | P00918 | 9/20 | 0.53 |
| ▸ | CA4 | P22748 | 9/20 | 0.53 |
| ▸ | CA9 | Q16790 | 9/20 | 0.53 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.50 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043177 | 0.92 | CA12 (0.49) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5048225 | 0.81 | KMT2A (0.55) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5043393 | 0.81 | CA12 (0.57) | CA12CA1CA2CA4CA9 | |
| SCHEMBL9836410 | 0.78 | CA12 (0.68) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5726322 | 0.78 | KDM4E (0.53) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5050303 | 0.75 | CA12 (0.51) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5043193 | 0.74 | TAS2R14 (0.56) | CA12CA1CA2CA4CA9 | |
| SCHEMBL4944598 | 0.74 | CA12 (0.68) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5046579 | 0.74 | CA12 (0.53) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5046527 | 0.73 | TDP1 (0.51) | CA12CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |