Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21103819 | 0.88 | SLC7A5 (0.50) | HDAC1SIRT2PTPN1SLC7A5 | |
| SCHEMBL5046394 | 0.83 | FFAR1 (0.54) | HDAC1SIRT2PTPN1MEN1KMT2A | |
| SCHEMBL27524253 | 0.82 | HDAC3 (0.46) | HDAC1HDAC3HDAC2HDAC8SMN1; SMN2 | |
| SCHEMBL5046423 | 0.82 | HDAC1 (0.46) | HDAC1SIRT2MEN1KMT2A | |
| SCHEMBL7930119 | 0.82 | ADRB2 (0.52) | CXCR1CXCR2 | |
| SCHEMBL5047991 | 0.81 | KDM4E (0.62) | HDAC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5046740 | 0.79 | HDAC1 (0.44) | HDAC1SIRT2PTPN1MEN1KMT2A | |
| SCHEMBL5046698 | 0.78 | HDAC1 (0.43) | HDAC1SIRT2PTPN1MEN1KMT2A | |
| SCHEMBL13840665 | 0.78 | SLC7A5 (0.56) | SIRT2PTPN1SLC7A5 | |
| SCHEMBL25146355 | 0.78 | HRH3 (0.50) | HDAC2HDAC8CXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |