Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
| ▸ | FAP | Q12884 | 2/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431495 | 1.00 | POLB (0.52) | POLBL3MBTL1DPP4DPP8PREP | |
| SCHEMBL3427333 | 1.00 | POLB (0.52) | POLBL3MBTL1DPP4DPP8PREP | |
| SCHEMBL1712666 | 0.86 | POLB (0.70) | POLBL3MBTL1DPP4DPP8PREP | |
| SCHEMBL5046483 | 0.86 | POLB (0.70) | POLBL3MBTL1DPP4DPP8PREP | |
| SCHEMBL3431498 | 0.86 | POLB (0.70) | POLBL3MBTL1DPP4DPP8PREP | |
| SCHEMBL13726715 | 0.78 | POLB (0.46) | POLBL3MBTL1DPP4DPP8PREP | |
| SCHEMBL3430695 | 0.78 | PREP (0.46) | POLBL3MBTL1DPP4DPP8PREP | |
| SCHEMBL3151491 | 0.78 | POLB (0.48) | POLBL3MBTL1CHRM2CHRM4CHRM1 | |
| SCHEMBL10667417 | 0.77 | ALDH1A1 (0.54) | POLBL3MBTL1 | |
| SCHEMBL1712663 | 0.76 | POLB (0.68) | POLBL3MBTL1DPP4DPP8PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | disclosed |