Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27556623 | 0.81 | HDAC3 (0.50) | MAPTSMN1; SMN2 | |
| SCHEMBL18025550 | 0.76 | SIRT2 (0.49) | PTPN1SIRT2CA12CA7CA9 | |
| SCHEMBL20981391 | 0.76 | SLC7A5 (0.45) | KMT2AGAASMN1; SMN2SLC7A5TDP1 | |
| SCHEMBL4873552 | 0.75 | SIRT2 (0.48) | PTPN1SIRT2CA12CA7CA9 | |
| Phenyl Propionic Acid SCHEMBL28543455 | 0.75 | FFAR1 (0.51) | PTPN1SIRT2CA12CA7CA9 | |
| SCHEMBL5043542 | 0.75 | PTPN1 (0.47) | PTPN1SIRT2CA12CA7CA9 | |
| SCHEMBL5043619 | 0.74 | CYP19A1 (0.58) | CA12CA7CA9CA14MAPT | |
| SCHEMBL5746476 | 0.74 | SIRT2 (0.47) | PTPN1SIRT2CA12CA7CA9 | |
| SCHEMBL13840665 | 0.72 | SLC7A5 (0.56) | PTPN1SIRT2SLC7A5 | |
| Methyl 3-Phenylpropanoate SCHEMBL168711 | 0.72 | TDP1 (0.68) | CA12CA7CA9CA14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |