Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048461 | 0.82 | KEAP1 (0.81) | CYP19A1KEAP1CA12CA9HDAC2 | |
| SCHEMBL4873552 | 0.78 | SIRT2 (0.48) | ALDH1A1CA12CA9CA7CA14 | |
| SCHEMBL4662858 | 0.77 | CYP19A1 (0.74) | CYP19A1KEAP1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5746476 | 0.77 | SIRT2 (0.47) | ALDH1A1CA12CA9CA7CA14 | |
| SCHEMBL20981392 | 0.77 | KEAP1 (0.63) | KEAP1PRMT1ALDH1A1CA12CA9 | |
| SCHEMBL9464524 | 0.76 | CA12 (0.61) | ALDH1A1CA12CA9MAPTCA7 | |
| SCHEMBL10205766 | 0.76 | CYP19A1 (0.72) | CYP19A1ALDH1A1MAPTTBXAS1TBXA2R | |
| SCHEMBL5043542 | 0.76 | PTPN1 (0.47) | ALDH1A1CA12CA9CA7CA14 | |
| SCHEMBL5046394 | 0.75 | FFAR1 (0.54) | ALDH1A1HTTATMLMNA | |
| SCHEMBL1048486 | 0.75 | AKR1C3 (0.66) | CYP19A1KEAP1ALDH1A1MAPTHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |