Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 11/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA4 | P22748 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049393 | 0.95 | PTGER2 (0.54) | PTGER2CYP11B1CA12CA1CA2 | |
| SCHEMBL5043544 | 0.91 | TAS2R14 (0.57) | PTGER2TAS2R14CA12CA1CA2 | |
| SCHEMBL13398750 | 0.91 | PTGER2 (0.52) | PTGER2CYP11B1TAS2R14PDE4APDE4B | |
| SCHEMBL13626605 | 0.91 | PTGER2 (0.51) | PTGER2CYP11B1CA12CA1CA2 | |
| SCHEMBL5049409 | 0.91 | TAS2R14 (0.51) | PTGER2TAS2R14CA12CA1CA2 | |
| SCHEMBL13398810 | 0.91 | PTGER2 (0.53) | PTGER2CYP11B1TAS2R14CA12CA1 | |
| SCHEMBL5046892 | 0.91 | PTGER2 (0.57) | PTGER2CYP11B1CA12CA1CA2 | |
| SCHEMBL5046393 | 0.90 | PTGER2 (0.52) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5043153 | 0.88 | PTGER2 (0.53) | PTGER2CYP11B1 | |
| SCHEMBL5043584 | 0.87 | PTGER2 (0.48) | PTGER2TAS2R14PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |