Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046005 | 0.80 | HDAC3 (0.59) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL5046007 | 0.80 | HDAC3 (0.59) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL1588287 | 0.79 | NPSR1 (0.51) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL6030315 | 0.78 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL70702 | 0.77 | DAO (0.63) | ALDH1A1L3MBTL1HPGDNPSR1PPARG | |
| SCHEMBL6030810 | 0.76 | HDAC3 (0.76) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL6030805 | 0.76 | HDAC3 (0.76) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL5046183 | 0.76 | HDAC6 (0.48) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL13753379 | 0.76 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL5047907 | 0.75 | HDAC3 (0.58) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396944-B2 | Thiophene derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2008-07-08 | — | — | US | disclosed |
| US-20070232602-A1 | Thiophene Derivatives, Their Manufacture and Use as Pharmaceutical Agents | HOFFMAN-LA ROCHE INC. | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232602-A1 | Thiophene Derivatives, Their Manufacture and Use as Pharmaceutical Agents | TPMT, ABCB1, CYP3A5 | ALDH1A1 129/4885L3MBTL1 3382/4885HDAC3 3854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.