Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 7/20 | 0.44 |
| ▸ | FNTB | P49356 | 7/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043018 | 0.91 | TLR7 (0.50) | MEN1KMT2ANR1H2NR1H3FNTA | |
| SCHEMBL6058775 | 0.91 | MEN1 (0.49) | MEN1KMT2ANR1H2NR1H3FNTA | |
| SCHEMBL5048029 | 0.89 | FFAR1 (0.47) | MEN1KMT2ANR1H2NR1H3FNTA | |
| SCHEMBL5046352 | 0.87 | FNTA (0.45) | MEN1KMT2ANR1H2NR1H3FNTA | |
| SCHEMBL8211041 | 0.86 | CA12 (0.52) | MEN1KMT2ANR1H2NR1H3PTGER2 | |
| Hydrochloric Acid SCHEMBL5046437 | 0.85 | CA12 (0.51) | MEN1KMT2ANR1H2NR1H3PTGER2 | |
| SCHEMBL5049429 | 0.85 | PTGER2 (0.55) | PTGER2 | |
| SCHEMBL5050570 | 0.84 | PTGER2 (0.51) | MEN1KMT2ANR1H2NR1H3FNTA | |
| SCHEMBL5046836 | 0.83 | TAS2R14 (0.53) | MEN1KMT2A | |
| SCHEMBL5043195 | 0.80 | TLR7 (0.47) | MEN1KMT2ANR1H2NR1H3FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |