Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | GRN | P28799 | 2/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | PIK3R5 | Q8WYR1 | 3/20 | 0.44 |
| ▸ | PIK3R3 | Q92569 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047327 | 0.89 | PARP1 (0.48) | MEN1KMT2ANOS1MAPK14GRN | |
| SCHEMBL1407899 | 0.84 | NCF1 (0.49) | MEN1KMT2ANOS1MAPK14NCF1 | |
| SCHEMBL30704930 | 0.84 | NCF1 (0.49) | MEN1KMT2ANOS1MAPK14NCF1 | |
| SCHEMBL10070685 | 0.83 | NCF1 (0.47) | MEN1KMT2ANOS1MAPK14NCF1 | |
| SCHEMBL2725769 | 0.78 | GRN (0.51) | MAPK14GRNSORT1KLKB1RAF1 | |
| SCHEMBL2724155 | 0.77 | PARP1 (0.48) | MAPK14GRNSORT1PARP1PARP2 | |
| SCHEMBL26921860 | 0.76 | MAPK14 (0.42) | MEN1KMT2AMAPK14PIK3CDPIK3R2 | |
| SCHEMBL26923141 | 0.76 | MAPK14 (0.51) | MAPK14TNFDDR2RAF1BRAF | |
| SCHEMBL5048482 | 0.75 | RIPK2 (0.58) | KMT2AMAPK14GRNSORT1KLKB1 | |
| SCHEMBL1695879 | 0.75 | NCF1 (0.48) | MEN1KMT2ANOS1NCF1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | NOVARTIS AG | 2011-12-08 | — | — | US | claimed |
| US-20080287427-A1 | Bicyclic Amides as Kinase Inhibitors | NOVARTIS AG (CH) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K19 | MEN1 1929/4885KMT2A 800/4885NOS1 2637/4885 |
| US-20080287427-A1 | Bicyclic Amides as Kinase Inhibitors | MAP3K20, MAP3K1, MAP3K19 | MEN1 2018/4885KMT2A 912/4885NOS1 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.