Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL226179 | 0.93 | HTR2A (0.47) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL226180 | 0.93 | HTR2A (0.47) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL230687 | 0.80 | HTR2A (0.56) | HTR2CHTR2AHTR7HTR6DRD2 | |
| SCHEMBL2533780 | 0.80 | MGLL (0.48) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL227582 | 0.80 | MGLL (0.48) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL227583 | 0.80 | MGLL (0.48) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL2533784 | 0.80 | MGLL (0.48) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL227981 | 0.79 | HTR2A (0.59) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL227980 | 0.79 | HTR2A (0.59) | HTR2CSMN1; SMN2LMNAHTTHTR2A | |
| SCHEMBL229208 | 0.76 | SMN1; SMN2 (0.56) | HTR2CSMN1; SMN2LMNAHTTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987019-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093540-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | disclosed |