Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 17/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041780 | 0.88 | SLC6A9 (0.63) | SLC6A9KCNH2SLC6A5CYP3A4CYP2C9 | |
| SCHEMBL4423788 | 0.85 | SLC6A9 (0.73) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5045531 | 0.84 | SLC6A9 (0.71) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5041433 | 0.82 | SLC6A9 (0.73) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5047631 | 0.80 | SLC6A9 (0.50) | SLC6A9KCNH2 | |
| SCHEMBL5047807 | 0.79 | SLC6A9 (0.58) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5038209 | 0.78 | SLC6A9 (0.75) | SLC6A9KCNH2SLC6A5HTTL3MBTL1 | |
| SCHEMBL4423405 | 0.76 | SLC6A9 (0.64) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL4425004 | 0.76 | SLC6A9 (0.70) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5037700 | 0.76 | SLC6A9 (0.54) | SLC6A9KCNH2SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |